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Invitrogen™ Human Stem Cell Factor (SCF), Recombinant Protein

Recombinant Protein

Marca:  Invitrogen™ RP8631

Detalles adicionales : Peso : 0.01000kg

Código de producto. 11519151

  • 297.00€ / 10 microgramos
Fecha estimada de envío: 20-06-2022
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Descripción

Descripción

Stem Cell Factor (human) Recombinant Protein, RP-8631, from Invitrogen.

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist. Recombinant human SCF is a non-glycosylated protein, containing 165 amino acids, with a molecular weight of 18.4 kDa Purity is typically greater than 98% and endotoxin level less than 1 EU/ug. The expected biological activity (ED50) is determined by the dose-dependent stimulation of Human TF-1 cells and is typically 1-5ng/mL. The specific activity of this protein is 1x10^6 units/mg. Reconstitute using sterile water at 0.1mg/mL and centrifuge prior to opening vial. Gently pipet solution down the sides of the vial. DO NOT VORTEX sample. Store reconstituted material at -20°C and add 0.1% BSA for additional stability. Amino acid sequence: MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA.
Especificaciones

Especificaciones

P21583
Control
10mM sodium phosphate with 50mM NaCl and no preservative; pH 7.5
∽18.4
7.5
10μg
-20°C, Avoid Freeze/Thaw Cycles
H-SCF
KITLG
Unlabeled
E. coli
Recombinant
0.1mg/mL
Lyophilized
4254
Human Stem Cell Factor (SCF)
purified
E. coli
RUO
Human Stem Cell Factor (SCF)
Human
Hu
Recombinant
Control
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Ofertas especiales

Ofertas especiales

in vitro research only.