p57 ^Kip2 Ab-3, Mouse Monoclonal Antibody,Lab Vision™ Epredia™

Description

p57^Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57^Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.

Host Species: Mouse

Clone: KP39

Isotype: IgG2b/κ

Species Reactivity: Human and Mouse. Others not known.

Epitope: Not determined

Immunogen: Recombinant human p57^Kip2 protein

Molecular Weight: 57kDa

Positive Control: LS174T cells, Colon CA or placenta

Cellular Localization: Nuclear

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting (Not suitable)
• Immunoprecipitation (Native verified)