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Nestin Mouse, anti-Human, Unconjugated, Clone: 10C2, STEMCELL Technologies
Mouse Monoclonal Antibody
Marca: Stemcell Technologies 60091
Detalles adicionales : Peso : 0.00110kg
Descripción
- The 10C2 antibody reacts with human nestin, a class VI intermediate filament (IF) protein expressed by embryonic neuroepithelial stem cells in the developing nervous system and by pancreatic islet and mesenchymal progenitor cells
- Nestin expression is also observed in glioblastomas and many primary and metastatic melanomas and it is a useful angiogenic marker to evaluate neovascularity of endothelial cells in tumors
- Nestin is required for the survival and renewal of neural progenitor cells and plays roles in cellular remodeling by forming heterodimers with vimentin or alpha-internexin, a process that appears to be tightly regulated by phosphorylation
- Nestin localizes to the growth cones during axon elongation in differentiating neurons and may play a role in growth cone guidance
- Nestin expression is down-regulated during differentiation, typically disappearing by embryonic stage E18
- The 10C2 antibody reportedly cross-reacts weakly with monkey nestin but not rodent nestin
Especificaciones
Nestin | |
Monoclonal | |
Unconjugated | |
100 μg | |
Cynomolgus, Human | |
Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Neurons |
Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence | |
10C2 | |
Mouse | |
Primary | |
IgG1 κ |