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ACROBiosystems Mouse GUCY2C / Guanylyl cyclase C Protein, Fc Tag

Marca:  ACROBiosystems GUC-M5254-100ug

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 17196351

  • 399.17€ / 100 microgramos
Fecha estimada de envío: 20-10-2022
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Descripción

Descripción

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 73.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

Powder
>95% as determined by SDS-PAGE
Mouse GUCY2C, Fc Tag (GUC-M5254) is expressed from human 293 cells (HEK293). It contains AA Val 20 - Met 433 (Accession # Q3UWA6-1).
-20°C
GUCY2C
Fc Tag
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
73.5 kDa
100 µg
Val 20 - Met 433
GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C
Unconjugated
PBS, pH7.4
HEK293
Mouse
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