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ACROBiosystems Mouse ErbB3 / Her3 Protein, His Tag

342.14€ - 2486.22€

Especificaciones

Número de acceso NP_034283.1
Formato Powder
Peso molecular 70.4 kDa
Pureza >95% as determined by SDS-PAGE
Fuente Mouse ErbB3, His Tag (ER3-M52H5) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - His 641 (Accession # Q61526-1).
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
17196281
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ACROBiosystems
ER3-M52H5-1MG
1 mg
2486.22€
1 miligramo
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Fecha estimada de envío: 05-01-2023
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17186281
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ACROBiosystems
ER3-M52H5-100UG
100 µg
342.14€
100 microgramos
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»
Fecha estimada de envío: 05-01-2023
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Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.
Descripción

Descripción

ErbB3, also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 70.4 kDa. The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

NP_034283.1
70.4 kDa
Mouse ErbB3, His Tag (ER3-M52H5) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - His 641 (Accession # Q61526-1).
-20°C
ErbB3
His Tag
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Ser 20 - His 641
ERBB3,HER3,LCCS2,MDA-BF-1,MGC88033,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3
Unconjugated
PBS, pH7.4
HEK293
Mouse
SDS
Product Certifications