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STEMCELL Technologies Human Recombinant LIF

Leukemia inhibitory factor

Marca:  STEMCELL Technologies 78055

Detalles adicionales : Peso : 0.00110kg

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Código de producto. 17199451

  • 438.90€ / 50 microgramos
Fecha estimada de envío: 05-10-2022
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Descripción

Descripción

  • Leukemia inhibitory factor (LIF) is an interleukin 6 class cytokine that regulates a broad variety of developmental functions
  • After LIF binds to LIF receptor (LIFR), LIFR associates with gp130 and activates JAK/STAT and MAPK signaling
  • LIFR activation of STAT3 is essential for maintaining the mouse embryonic stem cell phenotype
  • Produced by the endometrium, LIF plays an important autocrine and paracrine role in implantation by regulating proliferation, invasion, and differentiation of trophoblasts following blastocyst attachment
  • Human LIF can be used for the maintenance of mouse embryonic stem cells, however mouse LIF cannot bind to the human receptor, thus rendering mouse LIF inactive
  • LIF is produced by CD4+ and activated regulatory T cells, and promotes Foxp3 expression, while repressing Th17 lineage-specific genes
Especificaciones

Especificaciones

CDF, Cholinergic differentiation factor, D Factor, DIA, Differentiation-inducing factor, Differentiation inhibitory activity, Differentiation-stimulating factor, Emfilermin, Hepatocyte-stimulating factor III, HILDA, Leukemia inhibitory factor, MLPLI
>95%
50 μg
Neural Cells, PSC-Derived; Neurons; Pluripotent Stem Cells
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