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ACROBiosystems Human Integrin alpha 10 beta 1 (ITGA10&ITGB1) Heterodimer Protein, His Tag&Tag Free
Marca: ACROBiosystems IT1-H52Wa-100ug
Detalles adicionales : Peso : 0.00010kg
Descripción
Human integrin alpha(10)I domain as a recombinant protein to reveal its ligand binding specificity. In general, alpha(10)I did recognize collagen types I-VI and laminin-1 in a Mg(2+)-dependent manner, whereas its binding to tenascin was only slightly better than to albumin. Alpha 10 beta 1 is a known collagen-binding I domain integrin, in addition to α1β1, α2β1 and α11β1. GROGER found in the N-terminal domain of collagens I and III, is only weakly recognised by α10β1, an important collagen receptor on chondrocytes, contrasting with the other collagen-binding integrins.
Human ITGA10&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA10 and ITGB1, has a calculated MW of 126.6 kDa (ITGA10) and 83.7 kDa (ITGB1). Subunit ITGA10 is fused with an acidic tail at the C-terminus and followed by a polyhiEspecificaciones
| NP_003628.2 (ITGA10) and NP_002202.2 (ITGB1) | |
| 100 μg | |
| Phe 23 - Ser 1122 (ITGA10) and Gln 21 - Asp 728 (ITGB1) | |
| Integrin alpha 10 beta 1,ITGA10andITGB1 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 126.6 kDa (ITGA10) and 83.7 kDa (ITGB1) | |
| Human ITGA10&ITGB1; Heterodimer Protein, His Tag&Tag; Free (IT1-H52Wa) is expressed from human 293 cells (HEK293). It contains AA Phe 23 - Ser 1122 (ITGA10) and Gln 21 - Asp 728 (ITGB1) (Accession # O75578-1 (ITGA10) and P05556-1 (ITGB1)). | |
| -20°C | |
| Integrin alpha 10 beta 1 | |
| Human | |
| 50 mM Tris, 150 mM NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |