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ACROBiosystems Human IL-23 R Protein, Fc Tag

Marca:  ACROBiosystems ILR-H5254-100ug

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16477769

  • 391.16€ / 100 microgramos
Fecha estimada de envío: 01-08-2022
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Descripción

Descripción

Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

NP_653302.2
64.5 kDa
100 µg
Gly 24 - Gly 355
IL-23 R,IL-23 Receptor
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human IL-23 R, Fc Tag (ILR-H5254) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Gly 355 (Accession # Q5VWK5-1).
-20°C
IL-23 R
Fc Tag
Less than 1.0 EU / µg by the LAL method.
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