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ACROBiosystems Human Her2 / ErbB2 (23-450) Protein, Fc Tag

Marca:  ACROBiosystems HE2-H525X-25UG

Detalles adicionales : Peso : 0.00001kg

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Código de producto. 15896927

  • 323.91€ / 25 microgramos
Fecha estimada de envío: 07-02-2023
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Descripción

Descripción

Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 73.8 kDa. The protein migrates as 95-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

NP_004439.2
73.8 kDa
25 µg
Thr 23 - Ile 450
ERBB2,CD340,HER-2/neu,HER2,MLN19,NEU,NGL,TKR1
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human Her2 (23-450), Fc Tag (HE2-H525x) is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Ile 450 (Accession # P04626-1).
-20°C
Her2
Fc Tag
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Videos
SDS
Documentos

Documentos

Certificados
Ofertas especiales

Ofertas especiales