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Invitrogen™ Human FGF-basic (FGF-2/bFGF) Recombinant Protein

Recombinant Protein

Marca:  Invitrogen™ RFGFB50

Detalles adicionales : Peso : 0.80000kg

Código de producto. 11848771

  • 638.00€ / 50 microgramos
Fecha estimada de envío: 10-06-2022
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Descripción

Descripción

Human Fibroblast Growth Factor Basic (FGF-basic) Recombinant Protein, RFGFB50, from Invitrogen.

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization. For dilution, use a buffer containing carrier protein, e.g. PBS with 1% BSA or a neutral media containing 10% FCS and freeze in aliquots at -70°C. Activity: The ED50 is determined to be <0.5ng/mL in a thymidine uptake assay using BaF3 cells, corresponding to a specific activity of >2 x10^6 units/mg. Reconstitute to 100ug/mL using distilled water.
Especificaciones

Especificaciones

P09038
Lyophilized
2247
purified
E. Coli
RUO
Human FGF basic
Human
Hu
Recombinant
ELISA, Immunoprecipitation, Western Blot
ELISA, Immunoprecipitation, Western Blot
TBS with no preservative
Human FGF basic
50μg
-20°C, Avoid Freeze/Thaw Cycles
Human Fibroblast Growth Factor Basic FGFB
FGF2
Unlabeled
E. coli
Recombinant
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