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ACROBiosystems Human Coagulation factor XI / FXI Protein, His Tag (active enzyme)
Marca: ACROBiosystems FXI-H52H5-500ug
Detalles adicionales : Peso : 0.00010kg
Descripción
Coagulation factor XI is also known as F11, PTA and FXI. Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Factor XI is synthesized in the liver and circulates in the plasma as a disulfide bond-linked dimer complexed with high molecular weight kininogen. Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa. Factor XI is converted into XIa via either the contact phase of blood coagulation or thrombin-mediated activation on the platelet surface. The resulting XIa converts factor IX into IXa, which subsequently activates factor X into Xa.
This protein carries a polyhistidine tag at the C-terminus. The proprotein is activated by factor XIIa (or XII) and cleaved after Arg-387 into the light chain with calculated MW of 28.7 kDa, which contains the active site, and the heavy chain with calculaEspecificaciones
| 69.9 kDa | |
| Human Coagulation factor XI, His Tag (FXI-H52H5) is expressed from human 293 cells (HEK293). It contains AA Glu 19 - Val 625 (Accession # P03951-1). | |
| -20°C | |
| Coagulation factor XI | |
| Human | |
| 25 mM HEPES, 150 mM NaCl, pH7.5 | |
| HEK293 | |
| Cytokines and Growth Factors |
| 500 μg | |
| Glu 19 - Val 625 | |
| Coagulation factor XI,FXI,PTA,F11 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |