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ACROBiosystems Cynomolgus Fc gamma RIIB / CD32b Protein, His Tag

SPR verified

Marca:  ACROBiosystems CDB-C5224-100ug

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 17186191

  • 342.14€ / 100 microgramos
Fecha estimada de envío: 14-10-2022
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Descripción

Descripción

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.8 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

NP_001271060.1
21.8 kDa
100 µg
Ala 46 - Pro 224
FCGR2B,CD32b,CD32,FCG2,IGFR2,CDw32
Unconjugated
PBS, pH7.4
HEK293
Cynomolgus
Powder
>90% as determined by SDS-PAGE
Cynomolgus CD32b, His Tag (CDB-C5224) is expressed from human 293 cells (HEK293). It contains AA Ala 46 - Pro 224 (Accession # Q8SPW3-1).
-20°C
Fc gamma RIIB / CD32b
His Tag
Less than 1.0 EU / µg by the LAL method.
MABSol™ Fc Receptors
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