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CD8a Mouse, anti-Human, PE, Clone: SK1, STEMCELL Technologies

Mouse Monoclonal Antibody

Marca:  Stemcell Technologies 60125PE

Detalles adicionales : Peso : 0.00110kg

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Código de producto. 17189151

  • 597.17€ / 100 tests
Fecha estimada de envío: 14-11-2022
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Descripción

Descripción

  • The SK1 antibody reacts with CD8a, a 32 - 34 kDa type I transmembrane glycoprotein that is a subunit of CD8
  • CD8 is a disulfide-bonded dimer, found either as a heterodimer of CD8a (α) and CD8b (β) subunits (i.e.αβ) or a homodimer (αα)
  • CD8 acts as a co-receptor to the T cell receptor (TCR) during T cell activation by binding MHC class I molecules presented by an antigen-presenting cell
  • It functions to strengthen the association between the TCR and MHC I-antigen complex and to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck
  • The CD8a chain binds to the α3 domain of class I MHC molecules
  • CD8 is expressed by a majority of thymocytes, a subset of mature peripheral blood T cells (T cytotoxic cells), a proportion of β T cells, and at lower levels by NK cells (which predominantly express CD8a homodimers)
Especificaciones

Especificaciones

CD8a
Monoclonal
PE
100 Tests
Human
T Cells, T Cells, CD8+
Flow Cytometry
SK1
Mouse
Primary
IgG1 κ
Videos
SDS
Documentos
Certificados
Ofertas especiales

Ofertas especiales