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CD40 Mouse, anti-Human, FITC, Clone: 5C3, STEMCELL Technologies
Mouse Monoclonal Antibody
Marca: Stemcell Technologies 60113FI
Detalles adicionales : Peso : 0.00110kg
Descripción
- The 5C3 antibody reacts with CD40, a 45 - 50 kDa type I transmembrane glycoprotein that is a member of the tumor necrosis factor receptor (TNFR) superfamily
- CD40 plays an important role in B cell development and is also involved in the process of B cell selection in germinal centers
- It facilitates T cell-B cell interactions for co-stimulation and immune regulation through engagement with CD154 (gp39), the CD40 ligand expressed on T cells
- In the presence of IL-4, or other stimuli, CD40 promotes B cell proliferation, induces immunoglobulin- (Ig) isotype class switching and rescues B cells from surface Ig-induced apoptosis
- CD40 is expressed on the surface of B cells, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, endothelial cells, basal epithelial cells, CD34+ hematopoietic progenitor cells, and primary carcinomas
- It is expressed at low levels, or not at all, on plasma cells
- The 5C3 antibody has been used for the activation of B cells in in vitro functional assays or for the induction of B cell proliferation
Especificaciones
| CD40 | |
| Monoclonal | |
| FITC | |
| 100 Tests | |
| Baboon, Cynomolgus, Rhesus Monkey, Chimpanzee, Human | |
| B Cells |
| Immunohistochemistry, Flow Cytometry, Functional Assay | |
| 5C3 | |
| Mouse | |
| Primary | |
| IgG1 κ |