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CD3 Mouse, anti-Human, APC, Clone: UCHT1, STEMCELL Technologies
Mouse Monoclonal Antibody
Marca: Stemcell Technologies 100-0448
Detalles adicionales : Peso : 0.00330kg
Descripción
- The UCHT1 antibody reacts with the ∼20 kDa CD3ε subunit of the human T cell receptor (TCR)/CD3 complex, which is expressed on the surface of ∼95% of mature T cells and NKT cells, and variably onthymocytes
- A majority of T cell neoplasms also express CD3
- The CD3 complex, which is assembled from combinations of CD3γ, δ, ε, η, and ζ subunits, associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR
- Activation of T cells by the TCR involves the cytoplasmic tails of the CD3 subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily
- Mutations in the CD3 subunits have been associated with various immunodeficiency disorders including severe combined immunodeficiency (SCID)
Especificaciones
CD3 | |
Monoclonal | |
APC | |
500 Tests | |
Chimpanzee, Human |
Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence | |
UCHT1 | |
Mouse | |
Primary | |
T Cells |