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CD25 Rat, anti-Mouse, PerCP-Cyanine5.5, Clone: PC61.5, STEMCELL Technologies
Rat Monoclonal Antibody
213.30€ - 589.95€
Especificaciones
| Antígeno | CD25 |
|---|---|
| Clon | PC61.5 |
| Aplicaciones | Immunohistochemistry, Flow Cytometry, Functional Assay, Blocking Assay |
| Clasificación | Monoclonal |
| Conjugado | PerCP-Cyanine5.5 |
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
|---|---|---|---|---|---|---|---|---|---|
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
|
17198401
|
Stemcell Technologies
60009PS.1 |
25 μg |
213.30€
25 microgramos |
Fecha estimada de envío: 14-05-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
|
17188401
|
Stemcell Technologies
60009PS |
100 μg |
589.95€
100 microgramos |
Fecha estimada de envío: 14-05-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
Descripción
- The PC61.5 antibody reacts with mouse CD25 (low-affinity interleukin‐2 receptor α chain or IL-2Rα), which is an ∼55 kDa type 1 transmembrane glycoprotein expressed on T and B cell progenitors, activated (but not resting) T and B cells, regulatory T (Treg) cells, dendritic cells, and activated monocytes and macrophages
- Expression of CD25, together with CD4 and FOXP3, is considered a phenotypic signature for Treg cells
- CD25 per se has low affinity for its IL-2 ligand but associates with CD122 (IL-2Rβ) and CD132 (IL-2Rγ) to form the high-affinity IL-2R receptor
- CD25 is necessary for receptor clustering and induction of signaling pathways involved in the activation and proliferation of lymphocytes
- Binding of the PC61.5 antibody inhibits binding of IL-2 to the low- and high-affinity receptors, which may result in inhibition of IL-2-dependent proliferation
- The epitope recognized by PC61.5 is distinct from the IL-2 binding site and from the epitopes recognized by antibodies 7D4 and 3C7
Especificaciones
| CD25 | |
| Immunohistochemistry, Flow Cytometry, Functional Assay, Blocking Assay | |
| PerCP-Cyanine5.5 | |
| Mouse | |
| Primary |
| PC61.5 | |
| Monoclonal | |
| Rat | |
| IgG1 λ |