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CD25 Rat, anti-Mouse, PerCP-Cyanine5.5, Clone: PC61.5, STEMCELL Technologies

Rat Monoclonal Antibody

Marca:  Stemcell Technologies 60009PS

Detalles adicionales : Peso : 0.00110kg

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Código de producto. 17188401

  • 517.37€ / 100 microgramos
Fecha estimada de envío: 15-12-2022
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Descripción

Descripción

  • The PC61.5 antibody reacts with mouse CD25 (low-affinity interleukin‐2 receptor α chain or IL-2Rα), which is an ∼55 kDa type 1 transmembrane glycoprotein expressed on T and B cell progenitors, activated (but not resting) T and B cells, regulatory T (Treg) cells, dendritic cells, and activated monocytes and macrophages
  • Expression of CD25, together with CD4 and FOXP3, is considered a phenotypic signature for Treg cells
  • CD25 per se has low affinity for its IL-2 ligand but associates with CD122 (IL-2Rβ) and CD132 (IL-2Rγ) to form the high-affinity IL-2R receptor
  • CD25 is necessary for receptor clustering and induction of signaling pathways involved in the activation and proliferation of lymphocytes
  • Binding of the PC61.5 antibody inhibits binding of IL-2 to the low- and high-affinity receptors, which may result in inhibition of IL-2-dependent proliferation
  • The epitope recognized by PC61.5 is distinct from the IL-2 binding site and from the epitopes recognized by antibodies 7D4 and 3C7
Especificaciones

Especificaciones

CD25
Monoclonal
PerCP-Cyanine5.5
100 μg
Mouse
T Cells, T Cells, Regulatory
Blocking Assay, Functional Assay, Flow Cytometry, Immunohistochemistry
PC61.5
Rat
Primary
IgG1 λ
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