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CD117 (c-Kit) Rat, anti-Mouse, PE, Clone: ACK2, STEMCELL Technologies
Rat Monoclonal Antibody
170.10€ - 625.05€
Especificaciones
| Antígeno | CD117 (c-Kit) |
|---|---|
| Clon | ACK2 |
| Aplicaciones | Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence |
| Clasificación | Monoclonal |
| Conjugado | PE |
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
|---|---|---|---|---|---|---|---|---|---|
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
17108671
|
Stemcell Technologies
60034PE.1 |
50 μg |
170.10€
50 microgramos |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
|
17198661
|
Stemcell Technologies
60034PE |
200 μg |
625.05€
200 microgramos |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
Descripción
- The ACK2 antibody reacts with CD117 (c-Kit), an ∼145 kDa type 1 transmembrane receptor for c-Kit ligand (stem cell factor/steel factor) that is broadly expressed on hematopoietic stem cells in bone marrow, including pluripotent and erythroid progenitor cells and B and T lymphocyte precursors, as well as on mast cells
- CD117 belongs to the tyrosine kinase receptor family and possesses five immunoglobulin-like C2-type domains and a cytoplasmic protein kinase domain
- Binding of c-Kit ligand to CD117 induces dimerization and autophosphorylation, which activates several intracellular signaling pathways critical for the proliferation and differentiation of hematopoietic stem cells
- Signaling by CD117 is modulated by phosphatases and by rapid endocytosis and degradation of the receptor
- Mutations in CD117 are associated with various types of tumors and the piebald trait, an autosomal dominant abnormality of pigmentation
Especificaciones
| CD117 (c-Kit) | |
| Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence | |
| PE | |
| Mouse | |
| Primary |
| ACK2 | |
| Monoclonal | |
| Rat | |
| IgG2b κ |