CD117 (c-Kit) Rat, anti-Mouse, PE, Clone: ACK2, STEMCELL Technologies

Rat Monoclonal Antibody

Marca: Stemcell Technologies 60034PE

Código de producto. 17198661

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Descripción

The ACK2 antibody reacts with CD117 (c-Kit), an ∼145 kDa type 1 transmembrane receptor for c-Kit ligand (stem cell factor/steel factor) that is broadly expressed on hematopoietic stem cells in bone marrow, including pluripotent and erythroid progenitor cells and B and T lymphocyte precursors, as well as on mast cells
CD117 belongs to the tyrosine kinase receptor family and possesses five immunoglobulin-like C2-type domains and a cytoplasmic protein kinase domain
Binding of c-Kit ligand to CD117 induces dimerization and autophosphorylation, which activates several intracellular signaling pathways critical for the proliferation and differentiation of hematopoietic stem cells
Signaling by CD117 is modulated by phosphatases and by rapid endocytosis and degradation of the receptor
Mutations in CD117 are associated with various types of tumors and the piebald trait, an autosomal dominant abnormality of pigmentation

Especificaciones

Antígeno	CD117 (c-Kit)
Clasificación	Monoclonal
Conjugado	PE
Cantidad	200 μg
Especies diana	Mouse
Tipo de célula	Hematopoietic Stem and Progenitor Cells

Aplicaciones	Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence
Clon	ACK2
Especie del huésped	Rat
Primario o secundario	Primary
Isotype	IgG2b κ

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