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ACROBiosystems Biotinylated Human LOXL2 Protein, His, Avitag™

Biotinylated Protein

Marca:  ACROBiosystems LO2-H82E3-25ug

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16477849

  • 391.16€ / 25 microgramos
Fecha estimada de envío: 04-08-2022
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Descripción

Descripción

Lysyl oxidase homolog 2 is also known as LOXL2, Lysyl oxidase-like protein 2, which is expressed in many tissues, highest expression in reproductive tissues, placenta, uterus and prostate, Up-regulated in a number of cancers cells and tissues. LOXL2 mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOXL2 acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. LOXL2 acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 87.8 kDa.
Especificaciones

Especificaciones

Powder
PBS, pH7.4
Biotinylated Human LOXL2, His,Avitag (LO2-H82E3) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Gln 774 (Accession # Q9Y4K0-1).
-20°C
LOXL2
His Tag and Avi Tag
MABSol™ Biotin Labeled Proteins
87.8 kDa
25 µg
Gln 26 - Gln 774
Lysyl oxidase homolog 2,LOXL2
Precision Avi
HEK293
Human
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