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Invitrogen™ Mouse IL-4 Recombinant Protein
Recombinant Protein
Marca: Invitrogen™ RP8666
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Descripción
IL-4 (mouse) Recombinant Protein, RP-8666, from Invitrogen.
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4. Recombinant mouse IL-4 is a non-glycosylated protein, containing 121 amino acids, with a molecular weight of 13.7 kDa. Purity is typically greater than 95% and endotoxin level less than 1 EU/ug. The expected biological activity (ED50) is determined by the dose-dependent induction of HT-2 cell proliferation and is typically less than 2ng/mL. The specific activity of this protein is 5x10^5 units/mg. Reconstitute using sterile water at 0.1mg/mL and centrifuge prior to opening vial. Gently pipet solution down the sides of the vial. DO NOT VORTEX sample. Store reconstituted material at -20°C and add 0.1% BSA for additional stability. Amino acid sequence: MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S.Especificaciones
P07750 | |
Control | |
16189 | |
20μg | |
-20°C, Avoid Freeze/Thaw Cycles | |
M-IL-4 | |
Il4 | |
Unconjugated | |
E. coli | |
Lyophilized | |
purified |
0.1mg/mL | |
0.1%TFA with no preservative | |
Mouse IL-4 | |
E. Coli | |
RUO | |
Mouse IL-4 | |
Mouse | |
Ms | |
Recombinant | |
Recombinant |