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TAB1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 27566-1-AP-150UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16815705

  • 319.00€ / 150 microlitros

Envío estimado: 21-10-2021

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Descripción

Descripción

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a domit-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Especificaciones

Especificaciones

TAB1
0.4 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q15750, Q8CF89
3′ Tab1, MAP3K7IP1, TAB1, TAK1 binding protein 1
Rabbit
IgG
150 μL
-20°C
Primary
10454, 66513
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
TAB1
Liquid
Tab1
TAB1 Fusion Protein Ag25576
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Videos
SDS
Documentos
Certificados