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Invitrogen™ Human SIK3, GST Tag Recombinant Protein
SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily. Recombinant human SIK3 (1-307) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Marca: Invitrogen™ PV6403
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Descripción
The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm. Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer. There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer. SIK3 is a novel tumor-associated antigen (TAA).
- Validated in LanthaScreen™ Kinase Binding Assay
- Protocols available for simple use and optimized performance
- Multiple pack sizes available for convenient use
Especificaciones
| Kinase Assay | |
| 10μg | |
| aa 59-365 | |
| Recombinant | |
| Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. |
|
| Serine/Threonine Kinase | |
| Baculovirus | |
| Recombinant, Fragment | |
| Serine/Threonine Kinases |
| 61.7 kDa | |
| QSK, SIK-3, L19, FLJ12240, KIAA0999 | |
| Human | |
| GST Tag | |
| Biochemical binding/kinetic | |
| SIK3 | |
| Kinases & Inhibitors | |
| Liquid |