Learn More
POLR3E Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA531931
Detalles adicionales : Peso : 0.01000kg
Descripción
Recommended positive controls: Jurakt. Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (82%), Xenopus laevis (80%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.Especificaciones
POLR3E | |
Polyclonal | |
Unconjugated | |
POLR3E | |
DNA-directed RNA polymerase III 80 kDa polypeptide; DNA-directed RNA polymerase III subunit RPC5; KIAA1452; POLR3E; polymerase (RNA) III (DNA directed) polypeptide E; polymerase (RNA) III (DNA directed) polypeptide E (80kD); polymerase (RNA) III subunit E; RGD1308086; RNA polymerase III 80 kDa subunit RPC5; RNA polymerase III polypeptide E; RNA polymerase III subunit 5; RNA polymerase III subunit C5; RNA polymerase III subunit E; RPC5; Sex-lethal interactor homolog; Sin; Sxl interactor | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
55718 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Western Blot | |
1 mg/mL | |
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7 | |
Q9NVU0 | |
POLR3E | |
Recombinant fragment corresponding to a region within amino acids 89 and 323 of Human POLR3E | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |