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Invitrogen™ PLK4 Recombinant Human Protein

PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases. Recombinant human PLK4 (1-836) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Marca:  Invitrogen™ PV6394

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15449023

  • 345.00€ / 10 microgramos


Fecha de envío estimada
del proveedor 05-09-2018
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Descripción

Descripción

PLK4 localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells.The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development.

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance
  • Multiple pack sizes available for convenient use
Especificaciones

Especificaciones

Target & Lead Identification & Validation|Kinase Biology|Kinase Proteins & Expression Reagents|Protein Biology|Enzyme & Protein Activity Assays|Kinase Activity|Protein Assays and Analysis|Industrial & Applied Science|Pharma & Biopharma
120.9kDa
Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.
Kinase Assay
Human
GST Tag
50mM Tris-HCl pH 7.5, 150mM NaCl, 0.25mM DTT, 10mM glutathione, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol
10μg
SAK, STK18
aa 1-836
Yes
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