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PKN2 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA534784
Detalles adicionales : Peso : 0.01000kg
Descripción
Recommended positive controls: 293T, A431. Predicted reactivity: Mouse (86%), Rat (86%), Bovine (91%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
PKN2 (PRK2), a close relative of the PKCs, is a regulator of mitosis and exit from cytokinesis. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.Especificaciones
PKN2 | |
Polyclonal | |
Unconjugated | |
PKN2 | |
6030436C20Rik; AI507382; cardiolipin-activated protein kinase Pak2; p140 kinase; PAK2; Pak-2; PKN gamma; PKN2; PRK2; PRKCL2; PRO2042; protease-activated kinase 2; protein kinase C-like 2; protein kinase N2; protein-kinase C-related kinase 2; RP5-905H16.1; serine/threonine kinase 7; serine/threonine-protein kinase N2; serine/threonine-protein kinase N2; serine/threonine-protein kinase N2-like; si:ch211-83f14.1; Stk7; wu:fa97c07 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
5586 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot | |
1 mg/mL | |
PBS with 20% glycerol and 0.01% thimerosal; pH 7 | |
Q16513 | |
PKN2 | |
Recombinant fragment contains a sequence corresponding to a region within amino acids 487 and 984 of PKN2 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |