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Phospho-IR/IGF1R beta (Tyr1162, Tyr1163) Monoclonal Antibody (S.326.5), Invitrogen™
Rabbit Monoclonal Antibody
Marca: Invitrogen MA515148
Detalles adicionales : Peso : 0.01000kg
Descripción
It is not recommended to aliquot this antibody. This antibody is not cross-reactive with other related tyrosine-phosphorylated tyrosine kinases.
Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites. Phosphorylation of these three tyrosine residues is necessary for kinase activation. Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation.Especificaciones
Phospho-IR/IGF1R beta (Tyr1162, Tyr1163) | |
Monoclonal | |
243 μg/mL | |
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5 | |
P06213, P08069, P15127, P15208, P24062, Q60751 | |
IGF1R, INSR | |
Synthetic phosphopeptide corresponding to residues surrounding pTyr1135/1136 of human IGF-I receptor β | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Western Blot | |
S.326.5 | |
Unconjugated | |
INSR | |
IGF1 Receptor beta, IGF-I Receptor beta, IGF1R beta, CD221, IGFIR, IGFR, JTK13, IGF-I receptor, insulin-like growth factor I receptor, soluble IGF1R variant 1, soluble IGF1R variant 2, CD220, HHF5, INSR, Insulin receptor beta | |
Rabbit | |
Affinity chromatography | |
RUO | |
16001, 16337, 24954, 25718, 3480, 3643 | |
-20°C | |
Liquid |