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OPA1 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 1B2D8, Proteintech
Mouse Monoclonal Antibody
Marca: Proteintech 66583-1-IG-150UL
Detalles adicionales : Peso : 0.00010kg
Descripción
OPA1 is a dynamin-related GTPase that is critical for the maintece of mitochondrial morphology and mtDNA. The most commonly associated phenotype with OPA1 mutations is heterozygous optic atrophy, a heterozygous domit trait that causes reduced visual clarity and sometimes blindness. The disease usually begins in childhood and increases in severity throughout the life of affected individuals. Usually, this phenotype is attributed to the degeneration of optic nerve fibers. Interestingly, the same type of nerve degeneration seems to be partially causative of certain schizophrenia characteristics. OPA1 dysfunction also seems to be implicated in this case; mitochondrial networks associated with critical nerves seem to link schizophrenia and OPA1. The dysfunction is associated with issues with apoptosis and normal cellular metabolic regulation, all regulated through OPA1.Especificaciones
OPA1 | |
Monoclonal | |
1 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
O60313, P58281, Q2TA68 | |
Opa1 | |
OPA1 Fusion Protein Ag26868 | |
150 μL | |
Primary | |
Human, Mouse, Porcine, Rat | |
Antibody | |
IgG2b |
Western Blot | |
1B2D8 | |
Unconjugated | |
OPA1 | |
KIAA0567, largeG, MGM1, NTG, OPA1, Optic atrophy protein 1 | |
Mouse | |
Protein A | |
RUO | |
100522705, 171116, 4976, 74143 | |
-20°C | |
Liquid |