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Invitrogen™ Novex™ MMP-2 Human ELISA Kit

Detects and quantifies protein levels of human MMP-2 in serum, plasma, and cell culture supernatant

Marca:  Invitrogen™ KHC3082

Detalles adicionales : Peso : 0.10000kg

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Código de producto. 10410455

  • 794.00€ / cada uno


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Descripción

Descripción

MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components. MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains. The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. Functionally, MMP2 is involved in tissue remodeling. Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been found.
Especificaciones

Especificaciones

P08253
Biotin
4313
4 hr.
Pre-coated 96 well plate, Standard, Standard Dilution Buffer, Biotinylated Detection Antibody, Streptavidin-HRP, HRP Diluent, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
ELISA
RUO
Plasma, Serum, Supernatants
Plasma (50μL), Serum (50μL), Supernatants (50μL)
1 hr 20 min
Human
5.6%
HRP
0.78-50 ng/mL
Colorimetric Detection
Pre-coated plate, standard, detector antibody, Streptavidin-HRP, diluents, wash buffer, chromogen, stop solution, and plate covers
Colorimetric Microplate Reader
MMP-2
192 assays
<1 ng/mL
50μL
2-8°C
4 hr
MMP2
3.3%
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For Research Use Only. Not for use in diagnostic procedures.