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ACROBiosystems Mouse SIRP alpha / CD172a Protein, Mouse IgG2a Fc Tag, low endotoxin

low endotoxin

350.80€ - 2661.24€

Especificaciones

Número de acceso BAA13520.1 (G365D)
Peso molecular 65.0 kDa
Fuente Mouse SIRP alpha, Mouse IgG2a Fc Tag, low endotoxin (SIA-M5252) is expressed from human 293 cells (HEK293). It contains AA Lys 32 - Asn 373 (Accession # BAA13520.1 (G365D)).
Inmunógeno Lys 32 - Asn 373
Requisitos de almacenamiento -20°C
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
15877697
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ACROBiosystems
SIA-M5252-100UG
100 μg
350.80€
100 microgramos
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Fecha estimada de envío: 06-06-2024
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15887697
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ACROBiosystems
SIA-M5252-1MG
1 mg
2661.24€
1 miligramo
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Fecha estimada de envío: 06-06-2024
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Descripción

Descripción

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 65.0 kDa. The protein migrates as 90-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

BAA13520.1 (G365D)
Mouse SIRP alpha, Mouse IgG2a Fc Tag, low endotoxin (SIA-M5252) is expressed from human 293 cells (HEK293). It contains AA Lys 32 - Asn 373 (Accession # BAA13520.1 (G365D)).
-20°C
SIRP alpha
Mouse
50 mM Tris, 100 mM Glycine, pH7.5
HEK293
Immune Checkpoint Proteins
65.0 kDa
Lys 32 - Asn 373
SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1
Unconjugated
Mouse IgG Fc Tag
Less than 0.1 EU / μg by the LAL method.
Powder
>95% as determined by SDS-PAGE
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SDS
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