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ACROBiosystems Mouse CTLA-4 / CD152 Protein, His Tag

Marca:  ACROBiosystems CT4-M52H5-1MG

Detalles adicionales : Peso : 0.00001kg

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Código de producto. 15886527

  • 995.72€ / 1 miligramo
Fecha estimada de envío: 07-02-2023
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Descripción

Descripción

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.9 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

NP_033973
15.9 kDa
1 mg
Glu 36 - Phe 162
CTLA4,CD152
Unconjugated
PBS, pH7.4
HEK293
Mouse
Powder
>95% as determined by SDS-PAGE
Mouse CTLA-4, His Tag (CT4-M52H5) is expressed from human 293 cells (HEK293). It contains AA Glu 36 - Phe 162 (Accession # NP_033973).
-20°C
CTLA-4
His Tag
Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
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