Epredia™ Lab Vision™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1 Mouse Monoclonal Antibody, 200µg/mL, BSA and azide
Epredia™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results.
Marca: Epredia™ MS-1207-P0
Detalles adicionales : Peso : 1.00000kg
DescripciónSREBP-1 and -2 are transcription factors which participate in the control of cholesterol homeostasis. SREBPs proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. Upon activation of SREBP-1 or -2, an ∽480-500 amino acid, N-terminal cleavage fragment of these proteins enters the nucleus and activates transcription of enzymes and other proteins required for cholesterol synthesis. SCA (SREBP-cleavage activity) and caspase-3 proteases cleave SREBPs. SREBP proteins containing point mutations at caspase-3 cleavage sites (Asp460 in SREBP-1 and Asp468 in SREBP-2) do not become cleaved following induction of apoptosis, suggesting that SREBPs may play some role in apoptotic processes.
Host Species: Mouse
Species Reactivity: Human and Hamster. Others not known.
Epitope: aa 301-407
Immunogen: Recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1
Molecular Weight: 125kDa (precursor) and 60-70kDa (cleaved)
Positive Control: HeLa and IMR5 cells
Cellular Localization: Cytoplasmic and nuclear
- Western Blotting
- Immunoprecipitation (Not verified)
USA: RUO; Int'l: RUO
|SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1|
|Recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1|
|Immunoprecipitation, Western Blot|