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KDELR2 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA539163
Detalles adicionales : Peso : 0.00900kg
Descripción
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].Especificaciones
KDELR2 | |
Polyclonal | |
Unconjugated | |
KDELR2 | |
ERD22, ERD2.2 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
11014, 304290, 66913 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Western Blot | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
P33947, Q9CQM2, Q5U305 | |
KDELR2 | |
A synthetic peptide derived from the internal region of human ERD22 | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |