missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ Human IRAK1 Synthetic Peptide
Synthetic Peptide
Marca: Invitrogen™ PEP0001
Detalles adicionales : Peso : 0.01000kg
Descripción
IRAK Synthetic Peptide, PEP-0001, from Invitrogen.
Interleukin-1 receptor-associated kinase 1 (IRAK1) is a serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. IRAK is associated with Toll-like receptor (TLR) and IL-1R signaling pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK′s association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state. This peptide corresponds to 13 amino acids near the carboxy terminus of human IRAK.PEP-0001 can be used as a blocking peptide with polyclonal antibody PA5-19855.Especificaciones
3654 | |
purified | |
Human IRAK1 | |
-20°C | |
Liquid | |
Blocking Assay, Control | |
No | |
Peptide | |
RUO - research use only |
Human | |
P51617 | |
200 μg/mL | |
Synthetic Peptide | |
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2 | |
IRAK1 | |
0.02% sodium azide | |
50 μg | |
PBS |