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ACROBiosystems Human VLDL R Protein, His Tag

Marca:  ACROBiosystems VLR-H5227-100UG

Detalles adicionales : Peso : 0.00001kg

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Código de producto. 15877937

  • 371.89€ / 100 microgramos
Fecha estimada de envío: 07-02-2023
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Descripción

Descripción

The very-low-density-lipoprotein receptor (VLDL-R) is a lipoprotein receptor that shows considerable similarity to the lowdensity-lipoprotein receptor. VLDL R is a 130 kDa type I transmembrane protein in the LDL receptor family that plays a significant role in lipid metabolism and in nervous system development and function .This receptor has been suggested to be important for the metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, such as very-low-densitylipoprotein (VLDL), beta-migrating VLDL and intermediate-density lipoprotein. It is also one of the receptors of reelin, an extracellular matrix protein which regulates the processes of neuronal migration and synaptic plasticity. In humans, the VLDL-R is encoded by the VLDLR gene. A rare neurological disorder first described in the 1970s under the name “disequilibrium syndrome” is now considered to be caused by the disruption of VLDLR gene. The disorder was renamed VLDLR-associated cerebellar hypoplasia (VLDLRCH) after a 2005 study. It is associated with parental consanguinity and found in secluded communities such as the Hutterites. VLDLRCH is one of the two known genetic disorders caused by a disruption of reelin signaling pathway, along with Norman-Roberts syndrome.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 84.0 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Especificaciones

Especificaciones

NP_001018066.1
84.0 kDa
100 µg
Gly 28 - Ser 769
VLDLR,RP11-320E16.1,CHRMQ1,FLJ35024,VLDLRCH,VLDL receptor
Unconjugated
PBS, pH7.4
HEK293
Human
Powder
>90% as determined by SDS-PAGE
Human VLDL R, His Tag (VLR-H5227) is expressed from human 293 cells (HEK293). It contains AA Gly 28 - Ser 769 (Accession # P98155-2).
-20°C
VLDL R
His Tag
Less than 1.0 EU / µg by the LAL method.
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