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ACROBiosystems Human LAIR1 / CD305 Protein, Fc Tag

Marca:  ACROBiosystems LA1-H5252-100UG

Detalles adicionales : Peso : 0.00001kg

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Código de producto. 15887197

  • 431.88€ / 100 microgramos
Fecha estimada de envío: 07-02-2023
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Descripción

Descripción

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.1 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

AAH27899.1
42.1 kDa
100 µg
Gln 22 - His 163
LAIR1,CD305
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human LAIR-1, Fc Tag (LA1-H5252) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - His 163 (Accession # Q6GT x 8-1).
-20°C
LAIR-1
Fc Tag
Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
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