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ACROBiosystems Human IL-1 RII / CD121b Protein, Fc Tag
Marca: ACROBiosystems IL2-H4256-1MG
Detalles adicionales : Peso : 0.00001kg
Descripción
Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 63.9 kDa. The protein migrates as 68-74 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Especificaciones
| NP_004624.1 | |
| 1 mg | |
| Phe 14 - Glu 343 | |
| CD121b,IL1RB,IL1R2,CDw121b | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 63.9 kDa | |
| Human IL-1 RII, Fc Tag (IL2-H4256) is expressed from human 293 cells (HEK293). It contains AA Phe 14 - Glu 343 (Accession # NP_004624.1). | |
| -20°C | |
| IL-1 RII | |
| Human | |
| 50 mM Tris, 100 mM Glycine, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |