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ACROBiosystems Human CTLA-4 / CD152 Protein, mouse IgG2a Fc Tag, low endotoxin
low endotoxin
Marca: ACROBiosystems CT4-H52A4-100UG
Detalles adicionales : Peso : 0.00001kg
Descripción
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation and 100 kDa under non-reducing (NR) condition.Especificaciones
| NP_005205.2 | |
| 100 μg | |
| Ala 37 - Phe 162 | |
| CTLA4,CD152 | |
| Unconjugated | |
| Mouse IgG Fc Tag | |
| Less than 0.1 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 40.6 kDa | |
| Human CTLA-4, mouse IgG2a Fc tag, low endotoxin (CT4-H52A4) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # NP_005205.2). | |
| -20°C | |
| CTLA-4 | |
| Human | |
| 50 mM Tris, 100 mM Glycine, pH7.5 | |
| HEK293 | |
| Immune Checkpoint Proteins |