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ACROBiosystems Human Activin RIIB / ACVR2B Protein, His Tag

Marca:  ACROBiosystems ACB-H5226-200UG

Detalles adicionales : Peso : 0.00001kg

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Código de producto. 15895877

  • 314.52€ / 200 microgramos
Fecha estimada de envío: 03-05-2024
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Descripción

Descripción

Activin receptor type-2B (ACVR2B) is also known as ActR-IIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4).

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.5 kDa. The protein migrates as 22-44 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

NP_001097.2
200 μg
Ser 19 - Thr 137
ACVR2B,ACTRIIB,MGC116908
Unconjugated
His Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>90% as determined by SDS-PAGE
14.5 kDa
Human Activin RIIB, His Tag (ACB-H5226) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Thr 137 (Accession # Q13705-1).
-20°C
Activin RIIB
Human
PBS, pH7.4
HEK293
Other Recombinant Proteins
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