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GALR2 Polyclonal Antibody, Invitrogen™
Goat Polyclonal Antibody
Marca: Invitrogen PA518630
Detalles adicionales : Peso : 0.01000kg
Descripción
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.
GalR2 expression has been documented widely in the brain and in peripheral tissues including small intestine, heart, kidney, and liver. Localization data from rat CNS indicate high levels of expression in dorsal root ganglia, amygdala, and Purkinje neurons. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "e;turn-off"e; activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.Especificaciones
GALR2 | |
Polyclonal | |
Unconjugated | |
Galr2 | |
Gal receptor 2; Gal-2 receptor; GAL2-R; Galanin r2 receptor; galanin receptor 2; galanin receptor type 2; Galanin-2 receptor; Galnr2; GALR2; Gal-r2; GALR-2; mGalR; MGC125983; MGC125984 | |
Goat | |
Ammonium sulfate precipitation | |
RUO | |
8811 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Western Blot | |
0.5 mg/mL | |
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3 | |
O43603 | |
Galr2 | |
Synthetic peptide sequence (RYPLHSRELRTPRN) corresponding to the internal amino acids of GALR2 | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG |