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ACROBiosystems Cynomolgus / Rhesus macaque B7-1 / CD80 Protein, Fc Tag
Marca: ACROBiosystems CD0-C5252-1MG
Detalles adicionales : Peso : 0.00001kg
Descripción
B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 - 100 fold higher affinity than CD28 and is involved in the down regulation of the immune response.B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.5 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.Especificaciones
| 50.5 kDa | |
| Cynomolgus / Rhesus macaque B7-1, Fc Tag (CD0-C5252) is expressed from human 293 cells (HEK293). It contains AA Val 35 - Asn 242 (Accession # G7NXN7). In the region Val 35 - Asn 242, the AA sequence of Cynomolgus and Rhesus macaque B7-1 are homologus. | |
| -20°C | |
| B7-1 | |
| Cynomolgus Monkey, Rhesus Macaque | |
| Tris with Glycine, Arginine and NaCl, pH7.5 | |
| HEK293 | |
| Immune Checkpoint Proteins |
| 1 mg | |
| Val 35 - Asn 242 | |
| CD80,B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,LAB7 | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by reduced SDS-PAGE |