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CD123 (IL-3Rα) Mouse, anti-Human, Unconjugated, Clone: 6H6, STEMCELL Technologies

Mouse Monoclonal Antibody

Marca:  Stemcell Technologies 60110

Detalles adicionales : Peso : 0.00110kg

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Código de producto. 17199081

  • 186.20€ / 100 microgramos
Fecha estimada de envío: 08-11-2022
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Descripción

Descripción

  • The 6H6 antibody reacts with human CD123 (IL-3 receptor subunit α), an ∼70 kDa type I transmembrane glycoprotein belonging to the type I cytokine receptor family (type 5 subfamily) and the immunoglobulin (Ig) superfamily
  • CD123 constitutes the ligand-binding α chain of the heterodimeric IL-3 receptor
  • CD123 binds IL-3 with low affinity per se, but when associated with CD131 (the signal-transducing β chain of the receptor), high-affinity binding of IL-3 is observed
  • CD123 is expressed by hematopoietic progenitor cells, endothelial cells, basophils, eosinophils, mast cells, monocytes, macrophages, dendritic cells, megakaryocytes, a subset of B cells, and by neutrophils if cultured in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF)
  • IL-3 binding to CD123 stimulates proliferation, differentiation, and viability of hematopoietic cells
  • The 6H6 antibody does not inhibit binding of IL-3 to either CD123 or the IL-3 receptor
Especificaciones

Especificaciones

CD123 (IL-3Rα)
Monoclonal
Unconjugated
100 μg
Human, Sooty Mangabey, Rhesus Monkey
Dendritic Cells, Granulocytes and Subsets, Hematopoietic Stem and Progenitor Cells, Myeloid Cells
Immunofluorescence, Immunocytochemistry, Flow Cytometry, Western Blot, Immunohistochemistry
6H6
Mouse
Primary
IgG1 κ
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Ofertas especiales

Ofertas especiales