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Caspase 14 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA520297
Detalles adicionales : Peso : 0.01000kg
Descripción
A suggested positive control is Jurkat cell lysate. PA5-20297 can be used with blocking peptide PEP-0407.
Caspase 14 encodes a member of the cysteine-aspartic acid protease (caspase) family, which plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. Diseases associated with CASP14 include Ichthyosis, Congenital, Autosomal Recessive 12 and Autosomal Recessive Congenital Ichthyosis.Especificaciones
Caspase 14 | |
Polyclonal | |
Unconjugated | |
Casp14 | |
apoptosis-related cysteine protease; CASP14; CASP-14; caspase 14; caspase 14, apoptosis-related cysteine peptidase; caspase 14, apoptosis-related cysteine protease; Caspase14; caspase-14; Caspase-14 subunit p10, mature form; Caspase-14 subunit p17, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form; caspase-14; LOW QUALITY PROTEIN: caspase-14; MICE; Mini-ICE | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
12365, 23581, 299587 | |
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
Liquid |
Immunohistochemistry, Western Blot | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
O89094, P31944 | |
Casp14 | |
A 16 amino acid peptide from near the carboxy terminus of human caspase-14. | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |