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mGluR1 Mouse, Unlabeled, Clone: 20, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 610965
Detalles adicionales : Peso : 0.01100kg
Descripción
Glutamate is a major excitatory neurotransmitter and functions in multiple roles in the CNS. The functional diversity of glutamate is exemplified by two distinct groups of glutamate receptors: ionotropic and metabotropic. Coupling with G proteins provides the metabotropic glutamate receptors (mGluRs) with the capacity for intracellular signal transduction. Eight metabotropic glutamate receptors (mGluR1-8) and several Ca2+ sensing receptors belong to a novel G-protein coupled receptor (GPCR) family. The mGluRs possess the seven putative transmembrane domains which are characteristic of GPCR proteins. However, they exhibit no additional sequence homology to any member of other GPCR families. mGluR1 has large hydrophilic sequences in both the N- and C-terminal sides of the seven transmembrane domains. The sizable extracellular N-terminal domain is homologous to bacterial periplasmic binding proteins and serves as the glutamate binding site. mGluR1 activates phospholipase C (PLC), resulting in phosphoinositide turnover and, in turn, Ca2+; mobilization necessary for many signal transduction events.
Immunofluorescence, Western Blotting
Especificaciones
| mGluR1 | |
| Monoclonal | |
| 250μg/mL | |
| Metabotropic Glutamate Receptor-1 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
| Western Blot | |
| 20 | |
| Unconjugated | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Rat mGluR1 aa. 1042-1160 | |
| 150 μg | |
| Cell Biology | |
| Mouse, Rat | |
| IgG1 |
For Research Use Only.