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Ceruloplasmin Mouse, Unlabeled, Clone: 8, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 611488

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15875949

  • 321.48€ / 1 set
Fecha estimada de envío: 17-02-2023
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Descripción

Descripción

Ceruloplasmin (CP) is a copper-containing glycoprotein that carries approximately 90% of plasma copper. CP contains six copper atom binding sites and is prone to transfer its copper atoms to tissues, however it is not essential for copper transport. In cultured endothelial cells, CP release of copper in the cytosol inhibits nitric oxide synthase activation, and this may be important for regulating vascular tone in blood vessels. In addition to its copper binding role, CP has also been shown to have ferroxidase activity, which involves conversion of ferrous to
ferric iron. The iron metabolism disorder aceruloplasminemia results from mutations in CP and is characterized by massive iron deposits in liver, pancreas, brain, retina, and other tissues. CP is expressed in the liver, the splenic reticuloendothelial system, the bronchiolar epithelium of the lung, and the retina and brain. The cell-specific expression of CP in neural tissues may account for the neuropathologies associated with aceruloplaminemia, while the wide expression pattern of CP may demonstrate its importance in the regulation of copper and iron levels in many tissues.

Host Species: Mouse
Clone: 8
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Mouse ceruloplasmin aa. 233-355
Formula Weight [Chemical]: 132kDa

Immunofluorescence, Western Blotting

Especificaciones

Especificaciones

Ceruloplasmin
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse ceruloplasmin aa. 233-355
50 μg
Cell Biology
Rat, Mouse, Human
IgG1
Western Blot
8
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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Documentos

Documentos

Certificados
Ofertas especiales

Ofertas especiales

For Research Use Only.