missing translation for 'onlineSavingsMsg'
Learn More

Bub3 Mouse, Unlabeled, Clone: 31, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 611731

Detalles adicionales : Peso : 0.01000kg

 Ver más versiones de este producto

Código de producto. 15826019

  • 434.00€ / 1 set


Fecha estimada de envío
09-12-2019
Añadir a la cesta

Descripción

Descripción

Accurate chromosome segregation requires that all pairs of sister chromatids become appropriately attached to mitotic spindles before the onset of anaphase. Cell cycle checkpoints monitor kinetochore-microtubule interactions, so that cell cycle progression can be delayed until proper chromosome attachments are formed. In yeast, Bub1-3 genes are required for proper mitotic delay in response to unattached kinetochores. In mammals, the homologues to yeast Bub1 and Bub3 form a complex that binds kinetochores and has protein kinase activity. Bub3 contains four WD repeats, three in the N-terminus and one in the C-terminus, and a central Bub1-binding domain. During prophase and prometaphase, Bub3 localizes to the kinetochore before attachment to microtubules. In addition, taxol-induced formation of lagging chromosomes due to a delay of cell cycle progression increases the level of Bub3 co-localized with kinetochores, while correctly aligned chromosomes found in metaphase do not exhibit this co-localization. Thus, Bub3, in association with Bub1, may be important for sensing kinetochore attachment to microtubules during the prometaphase to metaphase transition.

Host Species: Mouse
Clone: 31
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human Bub3 aa. 4-16

Bioimaging, Immunofluorescence, Western Blotting

Especificaciones

Especificaciones

Bub3
31
Unconjugated
Affinity Purified
Human Bub3 aa. 4-16
150μg
Cell Biology
Primary
Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Videos
Documentos

For Research Use Only.