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ALKBH8 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Thermo Scientific PA558517
Detalles adicionales : Peso : 0.02000kg
Descripción
Immunogen sequence: LPPGLMVVEE IISSEEEKML LESVDWTEDT DNQNSQKSLK HRRVKHFGYE FHYENNNVDK DKPLSGGLPD ICESFLEKWL RKGYIKHKPD QMTINQYEPG QG Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 84%.
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).Especificaciones
ALKBH8 | |
Polyclonal | |
Unconjugated | |
ALKBH8 | |
4930562C03Rik; 8030431D03Rik; 9430088N01Rik; ABH8; alkB homolog 8, tRNA methyltransferase; AlkB homologue 8; alkB, alkylation repair homolog 8; alkB, alkylation repair homolog 8 (E. coli); Alkbh8; Alkylated DNA repair protein alkB homolog 8; LOW QUALITY PROTEIN: alkylated DNA repair protein alkB homolog 8; probable alpha-ketoglutarate-dependent dioxygenase ABH8; RGD1304687; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8; TRM9; TRMT9; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8; tRNA methyltransferase 9 homolog | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
91801 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry | |
0.1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q96BT7 | |
ALKBH8 | |
Recombinant protein corresponding to Human ALKBH8 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only