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Invitrogen™ Human Vitamin D3 Receptor Recombinant Protein

Código de producto. 15420714
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Cantidad:
30 μg
Tamaño de la unidad:
30 microgramos
Código de producto. Cantidad unitSize
15420714 30 μg 30 microgramos
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Código de producto. 15420714

Marca: Invitrogen™ A15670

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Descripción

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This full-length human Vitamin D3 Receptor is purified from recombinant baculovirus-infected insect cells and is soluble and functionally active with an observed Kd for [3H]-1a, 25-dihydroxyvitamin D3 of 2 nM. Vitamin D3 Receptor human recombinant protein is:, Flexible-use in your in-house assay or as part of our PolarScreenTM Competitor assays for a complete assay solution, Ready to use-active and native (untagged), Convenient-available in bulk sizes Contact us for bulk quantities or for assistance with other nuclear receptor assay needs, from assay development to library screening and beyond. Protein Form: Recombinant, Full Length

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T-cell proliferation and interleukin-2 (IL-2) gene expression, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription. The corresponding gene for the vitamin D receptor is NR1I1.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P11473
Concentración See Label
Para utilizar con (aplicación) Kinase Assay
Formulación proprietary buffer with no preservative
ID de gen (Entrez) 7421
Peso molecular 48 kDa
Nombre Human Vitamin D3 Receptor
Cantidad 30 μg
Estado normativo RUO - research use only
Alias de gen 1,25-dihydroxyvitamin D3 receptor; HGNC:12679; I79_025795; Nr1i1; Nuclear receptor subfamily 1 group I member 1; PPP1R163; protein phosphatase 1, regulatory subunit 163; vdr; vdr.S; vdr-A; vitamin D (1,25- dihydroxyvitamin D3) receptor; vitamin D (1,25- dihydroxyvitamin D3) receptor S homeolog; vitamin D (1,25-dihydroxyvitamin D3) receptor; vitamin D nuclear receptor variant 1; vitamin D receptor; vitamin D receptor protein; vitamin D receptor S homeolog; Vitamin D3 receptor; XELAEV_18015993mg; xVDR
Nombre común VDR
Símbolo de gen VDR
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Contenido y almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Sistema de expresión Baculovirus
Formulario Liquid
Grado de pureza o calidad 50% as determined by a SDS-PAGE gel stained with SimplyBlueTM SafeStain.
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