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TRAF-1 Antibody (TRAF1/3298) - Azide and BSA Free, Novus Biologicals™

Código de producto. 18217357 Tienda Bio Techne Productos
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Cantidad:
100 μg
Tamaño de la unidad:
100 microgramos
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18217357 100 μg 100 microgramos
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Código de producto. 18217357 Proveedor Novus Biologicals N.º de proveedor NBP279925

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Descripción

Mouse Monoclonal Antibody

TRAF-1 Monoclonal specifically detects TRAF-1 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno TRAF-1
Aplicaciones Immunohistochemistry, Immunohistochemistry (Paraffin), Peptide Array
Clasificación Monoclonal
Clon TRAF1/3298
Concentración 1 mg/mL
Conjugado Unconjugated
Dilución Immunohistochemistry 1-2 ug/ml, Immunohistochemistry-Paraffin 1-2 ug/ml, Protein Array
Formulación 10 mM PBS with No Preservative
Alias de gen EBI6MGC:10353, Epstein-Bar virus-induced protein 6, Epstein-Barr virus-induced protein 6, TNF receptor-associated factor 1
Símbolos de los genes TRAF1
Especie del huésped Mouse
Inmunógeno Recombinant fragment of human TRAF-1 protein (around aa 73-219) (exact sequence is proprietary) (Uniprot: Q13077)
Método de purificación Protein A or G purified
Cantidad 100 μg
Estado normativo RUO
Disciplina de investigación Apoptosis, Cancer, Cytokine Research
Primario o secundario Primary
Especificidad de la prueba This monoclonal antibody recognizes a protein of 52kDa, which is identified as TNFR1 (TNFR-associated factor 1). CD30-positive lymphoproliferations of the skin comprise 30% of all primary cutaneous T-cell lymphomas (CTCLs). Besides borderline cases this group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL). Although the two entities overlap clinically, histopathologically, immunopathologically and genetically, they differ considerably in their prognosis. In particular, common feature of both cases is histologically the presence of atypical lymphoid CD30-positive T blasts and genetically a clonal T-cell-receptor rearrangement. However, both cases differ considerably in their clinical course: Lesions of LyP regress spontaneously, whereas those of cALCL persist and may progress and spread. Moreover, LyP patients do not benefit from an aggressive radio- and/or chemotherapeutic approach, in contrast to patients with cALCL. Besides, LyP and cALCL differ strongly in the expression of TRAF1 (tumor necrosis factor receptor (TNFR)-associated factor 1), a component of TNFR signaling: Whereas tumor cells of most LyP cases (ca. 84%) show a strong TRAF1 expression, tumor cells of cALCL reveal TRAF1 expression in only a few cases (ca. 7%). Antibody to TRAF1 is highly useful for the differentiation of LyP and cALCL in patients with cutaneous CD30-positive lymphoproliferations.
Especies diana Human
Contenido y almacenamiento Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Formulario Purified
Isotype IgG2b κ
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