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Invitrogen™ Human Syk, GST Tag Recombinant Protein

Código de producto. p-7180610
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Cantidad:
10 μg
1 mg
Tamaño de la unidad:
1 miligramo
10 microgramos
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Código de producto. 11563587

Marca: Invitrogen™ PV3857

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Descripción

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length, Recombinant, Cytoplasmic.

Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P43405
Concentración See Label
Para utilizar con (aplicación) Kinase Assay
Formulación 50mM tris HCl with 0.5mM EDTA, 150mM NaCl, 0.02% Triton X-100, 50% glycerol, 2mM DTT and no preservative; pH 7.5
ID de gen (Entrez) 6850
Peso molecular 100.1 kDa
Nombre Human Syk, GST Tag
Intervalo de pH 7.5
Método de purificación Purified
Cantidad 10 μg
Requisitos de almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Estado normativo RUO
Alias de gen DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK
Nombre común Syk
Símbolo de gen Syk
Familia Quinasa SYK Kinase Family
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Etiqueta de proteína GST-tag
Secuencia Full length
Contenido y almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Entrada del ensayo Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity, Biochemical binding/kinetic
Grupo de cinasas Tyrosine Kinases
Condiciones de envío Dry Ice
Compatibilidad de sistemas LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™, Omnia™ Bulk Substrate
Posición de la etiqueta N-Terminal
Entrada diana SYK
Gen diana spleen tyrosine kinase
Sistema de expresión Baculovirus
Familia de proteínas Kinases & Inhibitors
Forma de proteína Full Length, Recombinant, Cytoplasmic
Formulario Liquid
Subtipo de proteína Cytoplasmic Tyrosine Kinases
Categoría de investigación Oncology, Signal Transduction
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